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Last modified: 10/01/2002 by
Open Discussion Forum
Please type any Wallerian degeneration-related
comments for open discussion below and hope that somebody will respond !
Some suggested issues:
- Protection of axons could open new therapeutic
routes in human neurological disease. Agree
? Disagree ?
Why ?
- Axon degeneration has been neglected both in
relation to its importance in human disease and as a fascinating biological
process. Agree ?
Why do you think this might be (e.g., it's hard to study axon
degeneration directly, eliminating the effects of cell bodies, myelin,
macrophages ? Or cell bodies get
more attention because they control most transcription and translation ?
Other ideas ?).
- Any suggestions how Wld, as a predominantly or
exclusively nuclear protein, could protect axons ?
- Do you think the protective mechanism is more
likely to be mediated by ubiquitination or NAD-metabolism
? Maybe elements from both
proteins ?
- What other ways are there to protect axons ?
Please
email your comments to Michael
Coleman or Weiqian Mi, we
will put your suggestions or comments on our Discussion Forum regularly.
