Publications

Selected publications since 1999

• "Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1."

Tscharntke M, Pofahl R, Chrostek-Grashoff A, Smyth N, Niessen C, Niemann C, Hartwig B, Herzog V, Klein H.W., Krieg T, Brakebusch C, Haase I. (2007)

J Cell Sci. 120(Pt 8), 1480-90 Medline

• "Hydrogen peroxide inhibits activity of the IGF-1 receptor kinase."

Schmitt TL, Klein H.W., Dröge W. (2006)

Redox Rep. 11(3), 105-109 Medline

• "Activation of a GST-tagged AKT2/PKB β"

Baer K, Lisinski I, Gompert M, Stuhlmann D, Schmolz K, Klein H.W., Al-Hasani H. (2005)

Biochim Biophys Acta 1725(3), 340-347 Medline

• "Interdependent Regulation of Insulin Receptor Kinase Activity by ADP and Hydrogen Peroxide"

Schmitt TL, Hotz-Wagenblatt A, Klein H.W., Dröge W. (2005)

Journal of Biological Chemistry 280 (5), 3795-3801 Medline

• "X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site"

Rufer AC, Thiebach L, Baer, K, Klein H.W., Henning M (2005)

Acta Crystallography F61 (Poster)

• "14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation"

Parvaresch S, Yesilkaya T, Baer K, Al-Hasani H, and Klein H.W. (2002)

FEBS Letters 532, 357-362 Medline

• "Activation of Insulin Receptor and IGF-1 Receptor Cytoplasmatic Domains: GST-Mediated Dimerization is Sufficient for Stimulating Dual Kinase Activity."

Rufer, A., Baer, K., Corona, T., Bergschneider, E., Parvaresch, S., Al-Hasani, H., and Klein, H.W. (2001)

Protein Modules in Cellular Signaling, NATO Science Series (Series I) IOS Press, Amsterdam, Netherlands

• "Dimerization-induced activation of soluble insulin/IGF-1 receptor kinases: An alternative mechanism of activation."

Baer, K., Al-Hasani, H., Parvaresch, S., Corona, T., Rufer, A., Noelle, V., Bergschneider, E., and Klein, H.W. (2001)

Biochemistry 40, 14268-14278 Medline

• Identification of Ser1275 and Ser1309 as autophosphorylation sites of the human insulin receptor in intact cells."

Tennagels, N., Telting, D., Parvaresch, S., Maassen, J.A., and Klein, H.W. (2001)

Biochem. Biophys. Res. Commun. 282, 387-391 Medline

• "Autophosphorylation of the two C-terminal tyrosine residues Tyr1316 and Tyr1322 modulates the activity of the insulin receptor kinase in vitro."

Tennagels, N., Bergschneider, E., Al-Hasani, H., and Klein, H.W. (2000)

FEBS Letters 479, 67-71 Medline

• "A single substitution of the insulin receptor kinase inhibits serine autophosphorylation in vitro: Evidence for an interaction between the C-terminus and the activation loop."

Noelle, V., Tennagels, N., and Klein, H.W. (2000)

Biochemistry 39, 7170-7177 Medline

• "Expression, purification, and characterization of the cytoplasmic domain of the human IGF-1 receptor using a baculovirus expression system."

Tennagels, N., Hube-Magg, C., Wirth, A., Noelle, V., and Klein, H.W. (1999)

Biochem. Biophys. Res. Commun. 260, 724-728 Medline

• Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro."

Lehr, S., Kotzka, J., Herkner, A., Klein, E., Siethoff, C., Knebel, B., Noelle, V., Brüning, J.C., Klein, H.W., Meyer, H.E., Krone, W., and Müller-Wieland, D. (1999)

Biochemistry 38, 151-159 Medline